Understanding how type 1 diabetes affects brain health over time
Official title: Identifying lifelong factors that impact brain health and outcomes in type 1 diabetes: The Cognition and Longitudinal Assessments of Risk Factors over 30 Years (CLARiFY) Diabetes Complications Study
Funded at University of Michigan at Ann Arbor · NIH-10904008 · Data updated 2026-11-12
This study is looking at how type 1 diabetes affects brain health and thinking skills over time, from childhood to adulthood, to help find ways to support better brain function for people living with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $439,740 |
| NIH project number | 5R01DK129320-04 |
| Project ID | NIH-10904008 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with type 1 diabetes, particularly those who have been living with the condition since childhood.
✕Less likely to help
Patients without a diagnosis of type 1 diabetes or those with other significant neurological conditions may not benefit from this research.
What this research studies
This research investigates the long-term effects of type 1 diabetes on brain health and cognitive function, focusing on individuals from childhood through adulthood. By following a cohort of patients over 30 years, the study aims to identify risk factors and resilience factors that influence cognitive outcomes. Participants will undergo assessments to track changes in brain structure and function, as well as cognitive abilities, to better understand the relationship between diabetes and brain health. The findings could help inform strategies for managing cognitive health in individuals with type 1 diabetes.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive health in individuals with type 1 diabetes.
How similar studies have gone: Previous longitudinal studies have shown promising results in understanding the impacts of chronic conditions on cognitive health, suggesting that this approach could yield valuable insights.
Where this research is happening
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University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Feldman, Eva Lucille — University of Michigan at Ann Arbor
- Study coordinator: Feldman, Eva Lucille
Related research
Other NIH-funded projects on the same topics.
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Lifelong factors affecting brain health in type 1 diabetes (CLARiFY)
This project follows people who were diagnosed with type 1 diabetes in childhood into adulthood to find which lifelong health and lifestyle factors link to brain changes and thinking problems.
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Obesity and GLP-1 treatment in young people with type 1 diabetes
A study in teens and young adults with type 1 diabetes and obesity will look at how a GLP-1–based obesity medicine affects body fat distribution, insulin resistance, and lipids.
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Understanding what raises heart disease risk in people with well-controlled type 1 diabetes
Researchers are studying why some people with type 1 diabetes still develop heart disease even when traditional risk factors are controlled.
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Understanding Heart Disease Risks in People with Well-Controlled Type 1 Diabetes
This project looks at why people with Type 1 diabetes might still get heart disease, even when their other health factors are well-managed.
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Understanding and treating obesity in young people with type 1 diabetes
This research explores how a medication for obesity, called a GLP-1 analogue, helps young people with type 1 diabetes manage their weight and reduce heart-related health risks.
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Investigating cardiovascular disease risks in people with well-controlled type 1 diabetes
This study is looking into why people with well-managed type 1 diabetes still have a higher chance of heart problems, by comparing their heart and blood samples with those from people with type 2 diabetes and those without diabetes, to find out what makes their risks different.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.