Understanding how type 1 diabetes affects brain health over time

Identifying lifelong factors that impact brain health and outcomes in type 1 diabetes: The Cognition and Longitudinal Assessments of Risk Factors over 30 Years (CLARiFY) Diabetes Complications Study

NIH-funded research University of Michigan at Ann Arbor · NIH-10904008

This study is looking at how type 1 diabetes affects brain health and thinking skills over time, from childhood to adulthood, to help find ways to support better brain function for people living with diabetes.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Michigan at Ann Arbor NIH-funded
Lab location1 site (Ann Arbor, United States)
Project IDNIH-10904008 on NIH RePORTER

What this research studies

This research investigates the long-term effects of type 1 diabetes on brain health and cognitive function, focusing on individuals from childhood through adulthood. By following a cohort of patients over 30 years, the study aims to identify risk factors and resilience factors that influence cognitive outcomes. Participants will undergo assessments to track changes in brain structure and function, as well as cognitive abilities, to better understand the relationship between diabetes and brain health. The findings could help inform strategies for managing cognitive health in individuals with type 1 diabetes.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals diagnosed with type 1 diabetes, particularly those who have been living with the condition since childhood.

Not a fit: Patients without a diagnosis of type 1 diabetes or those with other significant neurological conditions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved understanding and management of cognitive health in individuals with type 1 diabetes.

How similar studies have performed: Previous longitudinal studies have shown promising results in understanding the impacts of chronic conditions on cognitive health, suggesting that this approach could yield valuable insights.

Where this research is happening

Ann Arbor, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Brittle Diabetes Mellitus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.