Understanding how two proteins interact to form connections in the brain
Official title: Mechanism and Synaptic Function of Binding Between Proteins Kirrel3 and IgSF8
Funded at University of Utah · NIH-11057505 · Data updated 2026-11-12
This study is looking at how two important proteins in the brain work together to help brain cells communicate, which could give us clues about autism and other developmental disorders, ultimately helping patients understand more about these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $40,013 |
| NIH project number | 5F31MH134619-02 |
| Project ID | NIH-11057505 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related neurodevelopmental conditions.
✕Less likely to help
Patients with neurodevelopmental disorders not associated with synaptic protein interactions may not receive direct benefits from this research.
What this research studies
This research investigates the interactions between two proteins, Kirrel3 and IgSF8, which are crucial for the formation of synapses in the brain. By examining how these proteins bind and function together, the research aims to uncover the mechanisms that contribute to synaptic specificity, which is essential for proper neuronal communication. The study employs proteomic screening to identify binding partners and will explore the role of these proteins in the context of neurodevelopmental disorders, particularly autism spectrum disorder. Patients may benefit from insights gained about the cellular foundations of these conditions.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the biological mechanisms underlying neurodevelopmental disorders, potentially informing new therapeutic strategies.
How similar studies have gone: Previous research has shown success in understanding synaptic protein interactions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Weinbrom, Adam — University of Utah
- Study coordinator: Weinbrom, Adam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.