Understanding how TWIST1 acetylation affects cell development and disorders
Official title: The function of TWIST1 acetylation in cell fate and tissue development
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10726986 · Data updated 2026-11-12
This study is looking at how a specific change in a protein called TWIST1 might cause facial birth defects and some childhood cancers, and it aims to help kids with these conditions by finding new ways to understand and treat them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $448,500 |
| NIH project number | 1R21DE033147-01 |
| Project ID | NIH-10726986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with craniofacial disorders or those at risk for congenital anomalies.
✕Less likely to help
Patients with conditions unrelated to craniofacial development or pediatric cancers may not benefit from this research.
What this research studies
This research investigates the role of TWIST1 acetylation in the development of craniofacial disorders and related pediatric cancers. By studying mouse genetics and comparing affected cells to control cells, the researchers aim to uncover the genetic mechanisms that lead to these congenital anomalies. The project involves collaboration between two laboratories to explore how acetylation of the TWIST1 protein influences cell fate and contributes to tumor formation. Patients may benefit from insights gained into the genetic factors that cause craniofacial disorders and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with craniofacial disorders and related cancers.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in craniofacial disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Fakhouri, Walid D. — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Fakhouri, Walid D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.