Understanding how tumors resist treatment and spread in the body
Tumor-cell intrinsic and extrinsic determinants of drug resistance and metastasis
This study is looking at what helps cancer cells resist treatment and spread, so we can find better ways to help patients with tough-to-treat tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11230973 on NIH RePORTER |
What this research studies
This research investigates the factors within and around tumor cells that contribute to their ability to resist cancer treatments and spread to other parts of the body. By examining both intrinsic characteristics of the tumor cells and the external environment, the study aims to identify key mechanisms that drive drug resistance and metastasis. Patients may benefit from insights gained through this research, which could lead to more effective treatment strategies tailored to combat resistant tumors. The approach involves laboratory experiments and analysis of tumor samples to uncover these critical determinants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic cancer or those experiencing drug resistance in their treatment.
Not a fit: Patients with early-stage cancer that has not metastasized or those who are not currently undergoing treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with drug-resistant cancers.
How similar studies have performed: Previous research has shown success in identifying mechanisms of drug resistance and metastasis, suggesting that this approach could yield valuable insights.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Primeaux, Mark — University of Nebraska Medical Center
- Study coordinator: Primeaux, Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.