Understanding how tumors resist treatment and spread in the body
Official title: Tumor-cell intrinsic and extrinsic determinants of drug resistance and metastasis
Funded at University of Nebraska Medical Center · NIH-11230973 · Data updated 2026-11-12
This study is looking at what helps cancer cells resist treatment and spread, so we can find better ways to help patients with tough-to-treat tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $3,000 |
| NIH project number | 3F99CA294241-01S1 |
| Project ID | NIH-11230973 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with metastatic cancer or those experiencing drug resistance in their treatment.
✕Less likely to help
Patients with early-stage cancer that has not metastasized or those who are not currently undergoing treatment may not benefit from this research.
What this research studies
This research investigates the factors within and around tumor cells that contribute to their ability to resist cancer treatments and spread to other parts of the body. By examining both intrinsic characteristics of the tumor cells and the external environment, the study aims to identify key mechanisms that drive drug resistance and metastasis. Patients may benefit from insights gained through this research, which could lead to more effective treatment strategies tailored to combat resistant tumors. The approach involves laboratory experiments and analysis of tumor samples to uncover these critical determinants.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with drug-resistant cancers.
How similar studies have gone: Previous research has shown success in identifying mechanisms of drug resistance and metastasis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Primeaux, Mark — University of Nebraska Medical Center
- Study coordinator: Primeaux, Mark
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.