Understanding how tumors interact with the immune system to improve cancer treatments
The Center for Tumor-Immune Systems Biology at MSKCC
This study is looking at how to make cancer immunotherapies work better for everyone by figuring out why some tumors respond well to treatment while others don’t, using advanced technology and samples from both mice and patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10911887 on NIH RePORTER |
What this research studies
This research focuses on enhancing the effectiveness of cancer immunotherapies, particularly immune checkpoint blockade (ICB), which have shown promise in treating various solid tumors. The team at the Center for Tumor-Immune Systems Biology at MSKCC is investigating why some cancers respond well to these therapies while others do not. By combining computational biology, immunology, and cancer biology, they aim to analyze tumor-immune interactions through advanced techniques such as machine learning and spatial transcriptomics. This comprehensive approach includes studying both mouse models and patient tumor samples to identify new strategies for improving treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with solid tumors who have not responded to current immunotherapy treatments.
Not a fit: Patients with cancers that are already effectively treated by existing immunotherapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that benefit a broader range of patients.
How similar studies have performed: Previous research has shown promise in enhancing immunotherapy responses, but this approach aims to address specific limitations that have not yet been fully explored.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Leslie, Christina S — Sloan-Kettering Inst Can Research
- Study coordinator: Leslie, Christina S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.