Understanding how tumors interact with immune cells in their environment
Modeling and targeting tumor-immune signaling interactions in tumor microenvironment
This study is looking at how cancer cells and immune cells interact in the area around tumors to find new ways to improve cancer treatments, and it could help patients by discovering better options for fighting their cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11030855 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between tumors and immune cells within the tumor microenvironment (TME), which are crucial for tumor growth and response to therapies. By utilizing advanced technologies such as single-cell RNA sequencing and artificial intelligence models, the study aims to identify new molecular targets that can disrupt harmful signaling between tumor and immune cells. The approach includes creating 3D models of tumor environments and using genetic techniques to better understand these interactions. Patients may benefit from insights that could lead to more effective cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who are undergoing treatment or are interested in novel therapeutic approaches.
Not a fit: Patients with non-cancerous conditions or those not currently receiving cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that improve cancer treatment outcomes by targeting tumor-immune interactions.
How similar studies have performed: Other research has shown promise in using similar technologies to understand tumor-immune interactions, indicating potential for success in this approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Li, Fuhai — Washington University
- Study coordinator: Li, Fuhai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.