Understanding how tumors evolve and adapt over time
Towards a quantitative understanding of tumor evolution
['FUNDING_OTHER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10897759
This study looks at how tumors change when treated and how they interact with their surroundings, aiming to find better ways to target and treat cancer so that therapies can work more effectively.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10897759 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamic nature of tumors, particularly how they change and adapt in response to therapies. By examining the interactions between tumor cells and their surrounding environment, the study aims to uncover the complex patterns of tumor evolution. The researchers utilize quantitative methods to identify and target future dominant tumor subclones, which could lead to more effective treatment strategies. This work is crucial for understanding why some therapies fail and how to improve cancer treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with aggressive forms of cancer, such as glioblastoma, who are undergoing or have undergone therapy.
Not a fit: Patients with early-stage cancers or those not receiving treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer therapies by targeting the specific evolutionary patterns of tumors.
How similar studies have performed: Other research has shown promise in understanding tumor evolution, but this approach aims to provide a more structured and quantitative understanding, making it a novel contribution to the field.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RABADAN, RAUL — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: RABADAN, RAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers