Understanding how tumors and surrounding tissue affect cancer treatment response
Integrating tumor and stroma to understand and predict treatment response
['FUNDING_U01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10906788
This study is looking at how different types of pancreatic cancer tumors and their surrounding tissue work together to help doctors find the best treatment for patients, using a special test called PurIST to personalize care based on each person's tumor.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10906788 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between different types of pancreatic cancer tumors and their surrounding tissue, known as stroma, to better predict how patients will respond to treatments. By analyzing RNA sequencing data, the researchers have identified two main tumor subtypes that influence treatment outcomes. They have developed a specialized test, PurIST, to help determine the best treatment options for patients based on their tumor characteristics. The study aims to improve personalized treatment strategies for pancreatic cancer patients by understanding these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) who are seeking treatment options.
Not a fit: Patients with other types of cancer or those who do not have pancreatic ductal adenocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment plans tailored to individual patients based on their tumor and stroma characteristics.
How similar studies have performed: Previous research has shown promise in using molecular subtypes to guide treatment decisions, indicating that this approach could be effective.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YEH, JEN JEN — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: YEH, JEN JEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology