Understanding how tumors and immune cells interact in colorectal cancer
Dissecting the co-evolution of tumor and tumor-associated immune niches using orthotopic colorectal cancer models
This study is looking at how different cells in the body, including those from the immune system, work with colorectal cancer tumors and how this affects the cancer's growth and treatment, with the hope of finding better ways to help patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11074783 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between tumors and the immune system in colorectal cancer, focusing on how various cell types, including neural and endothelial cells, influence cancer progression and response to treatment. By utilizing advanced techniques such as single-cell sequencing and metabolic profiling, the study aims to uncover the mechanisms that drive metastasis and how these interactions can be manipulated for better therapeutic outcomes. Patients may benefit from insights gained into how their tumors interact with the immune system, potentially leading to more effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic colorectal cancer who are seeking innovative treatment options.
Not a fit: Patients with early-stage colorectal cancer or those not diagnosed with colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating metastatic colorectal cancer by targeting the interactions between tumors and immune cells.
How similar studies have performed: Other research has shown promising results in understanding tumor-immune interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Tavazoie, Sohail F. — Rockefeller University
- Study coordinator: Tavazoie, Sohail F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.