Understanding how tumors adapt to cancer treatments to improve therapy effectiveness.
Mechanistic maps of adaptive responses to therapeutic stress to optimize combination therapies.
This study is looking at how certain tough cancers, like triple-negative breast cancer and high-grade serous ovarian cancer, change when they face treatments, which can make them harder to treat; the goal is to create smart tools that help us understand these changes better so we can find the best treatment options for patients in the future.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11092754 on NIH RePORTER |
What this research studies
This research investigates how tumors, specifically in triple-negative breast cancer and high-grade serous ovarian cancer, adapt to the stress caused by therapies, which often leads to treatment resistance. The team aims to develop innovative algorithms to create detailed maps of these adaptive responses at a single-cell level. By understanding these mechanisms, they hope to predict how tumors will respond to different combinations of treatments and validate these predictions in future clinical trials. This approach involves a collaborative effort from experts in cancer biology, computational biology, and bioinformatics.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with triple-negative breast cancer or high-grade serous ovarian cancer.
Not a fit: Patients with other types of cancer or those who do not have treatment-resistant tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective combination therapies that prevent or overcome resistance in cancer treatments.
How similar studies have performed: Other research has shown promise in understanding tumor adaptation mechanisms, but this specific approach using mechanistic maps and predictive algorithms is relatively novel.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Mills, Gordon B. — Oregon Health & Science University
- Study coordinator: Mills, Gordon B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.