Understanding how tumor environments affect T cell behavior
Delineating the mechanisms by which tumor immunity multicellular networks shape T cell state
['FUNDING_CAREER'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11167327
This study is looking at how the area around tumors affects T cells, which are important for fighting cancer, to help find new ways to boost their ability to attack colorectal cancer.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11167327 on ClinicalTrials.gov |
What this research studies
This research investigates how the environment surrounding tumors influences T cells, which are crucial for the body's immune response against cancer. By examining the organization and interactions of various cells within tumor tissues, the study aims to uncover how these multicellular networks affect T cell activity. The research will utilize advanced techniques to map these cellular interactions and identify factors that shape the behavior of specific T cells in colorectal cancer. The ultimate goal is to find new strategies for enhancing the anti-tumor response of T cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer who have active tumor sites.
Not a fit: Patients with non-cancerous conditions or those who are not diagnosed with colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune system's ability to fight cancer.
How similar studies have performed: Previous research has shown promise in understanding tumor microenvironments and their impact on immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, JONATHAN HOWARD — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: CHEN, JONATHAN HOWARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.