Understanding how tumor environments affect colorectal cancer disparities among different racial and ethnic groups
Official title: Transcriptome and spatial analyses of tumor environment in addressing colorectal cancer racial and ethnical disparities
Funded at University of Washington · NIH-10907799 · Data updated 2026-11-12
This study is looking at why some racial and ethnic groups, especially African Americans and Alaska Natives, have worse outcomes with colorectal cancer, and it aims to find out how certain biological factors in their tumors might play a role, so we can better understand and address these differences.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F99CA284261-02 |
| Project ID | NIH-10907799 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include African American and Alaska Native individuals diagnosed with colorectal cancer.
✕Less likely to help
Patients from racial and ethnic groups not represented in the study may not receive direct benefits from this research.
What this research studies
This research investigates the differences in colorectal cancer outcomes among various racial and ethnic groups, particularly focusing on African American and Alaska Native populations. It aims to uncover the molecular and cellular factors that contribute to higher mortality rates in these groups, beyond just access to healthcare. By utilizing advanced techniques like spatial single-cell analyses, the study will explore the immune context within tumors to gain insights into how these factors influence cancer progression. This comprehensive approach seeks to enhance our understanding of colorectal cancer and its disparities.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for colorectal cancer patients from underrepresented racial and ethnic backgrounds.
How similar studies have gone: Previous research has shown that understanding tumor microenvironments can significantly impact cancer treatment strategies, suggesting this approach has potential for success.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Yin, Hang — University of Washington
- Study coordinator: Yin, Hang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.