Understanding how tumor cells interact with nerves in pancreatic cancer
Official title: Interrogate the interaction between tumor cells and nerves in the tumor microenvironment of pancreatic cancer
Funded at University of Texas Hlth Science Center · NIH-11170140 · Data updated 2026-11-12
This study is looking at how pancreatic cancer cells and nerve cells work together in the tumor area, focusing on certain proteins that might help the cancer spread, with the hope of finding better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $21,497 |
| NIH project number | 7R01CA169702-11 |
| Project ID | NIH-11170140 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma, particularly those experiencing perineural invasion.
✕Less likely to help
Patients with other types of cancer or those without pancreatic ductal adenocarcinoma may not benefit from this research.
What this research studies
This research investigates the complex interactions between tumor cells and nerve cells within the tumor microenvironment of pancreatic cancer. It focuses on the role of specific proteins, such as Annexin A2 and Semaphorin 3D, in promoting the invasion and spread of pancreatic ductal adenocarcinoma (PDAC). By examining these interactions, the research aims to uncover new mechanisms that could lead to more effective treatments for this aggressive cancer. Patients may benefit from insights that could improve therapeutic strategies targeting the tumor microenvironment.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that specifically target the interactions between tumor cells and nerves, potentially improving outcomes for patients with pancreatic cancer.
How similar studies have gone: Previous research has shown promising results in understanding the tumor microenvironment in pancreatic cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Zheng, Lei — University of Texas Hlth Science Center
- Study coordinator: Zheng, Lei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.