Understanding how tumor cells evade the immune system through specific pathways
Official title: Elucidating the role of tumor cell-intrinsic hypoxia inducible factor (HIF)-1α and HIF-2α pathway activation in tumor immune evasion
Funded at University of Chicago · NIH-11087543 · Data updated 2026-11-12
This study is looking at how certain factors in tumor cells help them hide from the immune system, which could help us find better ways to make cancer treatments work more effectively for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 12, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $189,195 |
| NIH project number | 5K08CA270394-03 |
| Project ID | NIH-11087543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cancers that are currently treated with immunotherapy but are not responding effectively.
✕Less likely to help
Patients with cancers that do not involve immune checkpoint inhibitors or those who are not candidates for immunotherapy may not benefit from this research.
What this research studies
This research investigates how certain pathways within tumor cells, specifically the hypoxia-inducible factors HIF-1α and HIF-2α, contribute to the ability of tumors to evade the immune system. By examining the tumor microenvironment and its effects on T cell responses, the study aims to uncover mechanisms that lead to resistance against immunotherapy treatments. Patients may benefit from this research as it could lead to improved strategies for enhancing the effectiveness of immunotherapies in cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy treatments for cancer patients.
How similar studies have gone: Other research has shown promising results in understanding tumor immune evasion, but the specific focus on HIF-1α and HIF-2α pathways in this context is relatively novel.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Trujillo, Jonathan a — University of Chicago
- Study coordinator: Trujillo, Jonathan a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.