Understanding how tumor cells and the immune system interact in brain cancer.
Metabolic interactions between tumor cells and the immunce system in GBM A potential Achilles heel of GBM for novel therapeutics
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-10897234
This study is looking at how different types of tumor cells in glioblastoma talk to immune cells, especially how some tumor cells can weaken the immune response while getting help from those immune cells, with the goal of finding new ways to improve treatment for people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10897234 on ClinicalTrials.gov |
What this research studies
This research investigates the metabolic interactions between different types of tumor cells in glioblastoma (GBM) and the immune system. It focuses on how fast-cycling and slow-cycling tumor cells communicate with immune cells, particularly how slow-cycling cells create an environment that suppresses immune responses while also receiving metabolic support from these immune cells. The study aims to explore potential therapeutic strategies that could disrupt these interactions to improve treatment outcomes for GBM patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who may benefit from novel therapeutic strategies targeting tumor-immune interactions.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that enhance the effectiveness of treatments for glioblastoma by targeting the metabolic interactions between tumor cells and the immune system.
How similar studies have performed: Other research has shown promise in targeting metabolic interactions in cancer, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DELEYROLLE, LOIC PIERRE — UNIVERSITY OF FLORIDA
- Study coordinator: DELEYROLLE, LOIC PIERRE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Treatment, Cancers