Understanding how tumor blood vessels affect cancer spread
Tumor Endothelial Cell Regulation of Pro-Metastatic Fibrin Matrices
This study is looking at how certain cells in tumors help lung and breast cancers spread, with the hope of finding new ways to treat these tough cancers and improve care for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11042159 on NIH RePORTER |
What this research studies
This research investigates the role of tumor endothelial cells in promoting the spread of lung squamous carcinoma and triple-negative breast cancer. By examining how these cells interact with the tumor microenvironment and contribute to the formation of fibrin matrices, the study aims to uncover new therapeutic targets. The approach includes advanced bioinformatics and novel cancer models to analyze the mechanisms behind tumor growth and metastasis. Patients may benefit from insights that could lead to improved treatments for these aggressive cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with lung squamous carcinoma or triple-negative breast cancer.
Not a fit: Patients with other types of cancer or those who do not have lung squamous carcinoma or triple-negative breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates for patients with lung squamous carcinoma and triple-negative breast cancer.
How similar studies have performed: Previous research has shown promising results in targeting tumor endothelial cells and fibrin matrices in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Pecot, Chad V — Univ of North Carolina Chapel Hill
- Study coordinator: Pecot, Chad V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.