Understanding how TULP3 affects cilia functions in human health
TULP3 integrates essential ciliary functions
This study is looking at tiny structures in our cells called primary cilia, which help cells understand their surroundings, and it focuses on a protein called TULP3 that keeps these cilia working well; by using special techniques, the researchers hope to learn how problems with cilia can lead to health issues like cancer and diabetes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10866216 on NIH RePORTER |
What this research studies
This research investigates the role of primary cilia, which are essential cellular structures that help cells sense their environment. The project focuses on TULP3, a protein that is crucial for the proper functioning of these cilia. By developing new techniques to study cilia, the researchers aim to uncover how defects in these structures can lead to various health issues, including cancer and diabetes. The study involves advanced methods like microscopy and mass spectrometry to analyze cilia behavior and the impact of genetic mutations on their function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic mutations affecting ciliary function or those suffering from related health conditions.
Not a fit: Patients with conditions unrelated to ciliary dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of diseases linked to ciliary dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding ciliary functions, making this approach both relevant and potentially impactful.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Turn, Rachel Elizabeth — Stanford University
- Study coordinator: Turn, Rachel Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.