Understanding how tuft cells affect norovirus infections
The role of tuft cells in norovirus pathogenesis
This study is looking at how special cells in the gut, called tuft cells, help the body respond to norovirus, which causes stomach illnesses, and it hopes to find new ways to treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10874574 on NIH RePORTER |
What this research studies
This research investigates the role of tuft cells in the infection process of norovirus, a virus that causes severe gastrointestinal illness. Using a mouse model, the study aims to uncover how tuft cells interact with norovirus and the immune system, which could lead to new insights into viral infections and potential treatments. The researchers have developed specialized mouse models and in vitro systems to explore these interactions in detail. By understanding these mechanisms, the research seeks to identify new therapeutic targets for combating norovirus infections.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals, particularly children and adults, who are at risk of norovirus infections or suffer from related gastrointestinal issues.
Not a fit: Patients who are not affected by norovirus or do not have gastrointestinal conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective antiviral treatments or vaccines for norovirus, significantly reducing illness and mortality associated with this virus.
How similar studies have performed: Other research has shown promise in understanding viral interactions with the immune system, but this specific focus on tuft cells in norovirus pathogenesis is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Wilen, Craig Brian — Yale University
- Study coordinator: Wilen, Craig Brian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.