Understanding how tubulin proteins shape neurons
Official title: Tools for mapping the tubulin landscape
Funded at University of Colorado Denver · NIH-10785950 · Data updated 2026-11-12
This study is exploring how certain proteins in brain cells help shape their structure and communication, and it's creating new tools to see and work with these proteins in real-time, which could lead to better treatments for brain disorders.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $155,201 |
| NIH project number | 1R03NS135453-01 |
| Project ID | NIH-10785950 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions or brain disorders that may be linked to tubulin dysfunction.
✕Less likely to help
Patients with conditions unrelated to neuronal structure or function may not benefit from this research.
What this research studies
This research focuses on the role of tubulin proteins in the architecture and signaling of neurons. It aims to develop innovative tools that allow scientists to visualize and manipulate specific tubulin isotypes in living cells, particularly TUBB3. By creating new antibodies and intrabodies, the research will help clarify how these proteins contribute to the formation and function of microtubule networks in neurons. This could lead to a better understanding of brain disorders and the development of new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to advancements in the treatment of brain disorders by improving our understanding of neuronal structure and function.
How similar studies have gone: Other research has shown promise in using similar approaches to study protein functions in living cells, indicating potential for success in this area.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Moore, Jeffrey Kyle — University of Colorado Denver
- Study coordinator: Moore, Jeffrey Kyle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.