Understanding how tubulin levels are regulated in human neurons
Investigation of the tubulin autoregulatory response at the mechanistic level and in the human neuron
This study looks at how brain cells manage a protein called tubulin, which is important for their health and function, to help us understand more about brain conditions and improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | U.s. National Inst/neuro/ds/stroke NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10499900 on NIH RePORTER |
What this research studies
This research investigates the autoregulatory response of tubulin, a key protein in neurons, which is crucial for various cellular processes such as cell division and transport. The study aims to explore how neurons maintain the balance of tubulin levels and the implications of this regulation for cellular health. By examining the mechanisms involved, including the role of specific proteins like TTC5, the research seeks to uncover insights that could lead to better understanding of neurological conditions. Patients may benefit from advancements in treatments targeting tubulin-related dysfunctions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that may be associated with tubulin dysregulation.
Not a fit: Patients with conditions unrelated to tubulin function or those without neurological issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurological disorders linked to tubulin regulation.
How similar studies have performed: While the specific focus on tubulin autoregulation in neurons is novel, related studies have shown success in understanding tubulin dynamics in other contexts.
Where this research is happening
Bethesda, United States
- U.s. National Inst/neuro/ds/stroke — Bethesda, United States (Active)
Researchers
- Principal investigator: Sarbanes, Stephanie Lena — U.s. National Inst/neuro/ds/stroke
- Study coordinator: Sarbanes, Stephanie Lena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.