Understanding how tuberculosis spreads by studying different strains in patients
Improved understanding of TB transmission by accounting for within-host heterogeneity of M. tuberculosis: A population-based molecular epidemiology study in a high HIV prevalent setting
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10764237
This study looks at how tuberculosis spreads in communities, especially where many people also have HIV, by exploring the different strains of TB bacteria that people can have, to help find better ways to stop outbreaks and keep everyone healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10764237 on ClinicalTrials.gov |
What this research studies
This research investigates how tuberculosis (TB) spreads in communities, particularly in areas with high rates of HIV. It focuses on the fact that many individuals with TB are infected with multiple strains of the bacteria, which can complicate our understanding of transmission. By examining the genetic diversity of these strains within patients, the study aims to identify patterns of transmission that are often overlooked. This could lead to better strategies for controlling TB outbreaks and protecting public health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis, particularly those living in high-incidence areas with a high prevalence of HIV.
Not a fit: Patients who do not have tuberculosis or are not in high-incidence areas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective interventions to reduce the spread of tuberculosis in communities.
How similar studies have performed: Previous research has shown that accounting for genetic diversity in pathogens can improve understanding of disease transmission, suggesting this approach has potential for success.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIN, SANGHYUK SAM — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: SHIN, SANGHYUK SAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.