Understanding how tuberculosis spreads among people on HIV treatment.
Official title: Defining drivers of TB transmission in the era of universal ART, and implications for finding the walking well
Funded at London Sch/hygiene & Tropical Medicine · NIH-10916220 · Data updated 2026-11-12
This study is looking at how tuberculosis spreads among people with HIV who are on treatment, to find out how many might have TB without showing any symptoms, so we can improve the ways we screen for TB and help keep everyone healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | London Sch/hygiene & Tropical Medicine NIH-funded |
| Lab location | 1 site (London, United Kingdom) |
| Project start | August 8, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $215,015 |
| NIH project number | 5R01AI147321-06 |
| Project ID | NIH-10916220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV, especially those receiving ART, and those who may have asymptomatic TB.
✕Less likely to help
Patients who are not living with HIV or do not have TB may not benefit from this research.
What this research studies
This research investigates the transmission dynamics of tuberculosis (TB) in individuals receiving antiretroviral therapy (ART) for HIV. It aims to identify how many people with TB are asymptomatic and therefore not detected by current screening methods. By comparing the infectiousness of HIV-positive individuals on ART to those not on treatment, the study seeks to develop more effective TB screening strategies that do not rely solely on symptoms. The research will take place in a high TB and HIV prevalence area in South Africa, focusing on cost-effective approaches to reduce TB transmission.
Why it matters
Potential benefit: If successful, this research could lead to improved TB screening methods that significantly reduce transmission rates, particularly among HIV-positive populations.
How similar studies have gone: Previous research has shown that innovative screening approaches can effectively identify asymptomatic TB cases, suggesting potential success for this study's methods.
Where this research is happening
-
London Sch/hygiene & Tropical Medicine
London, United Kingdom Active
Researchers
- Principal investigator: Grant, Alison — London Sch/hygiene & Tropical Medicine
- Study coordinator: Grant, Alison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.