Understanding how tuberculosis infection progresses to disease
Immune Determinants of the Course of Mycobacterium tuberculosis infection and Disease
This study is looking at how the immune system reacts to the bacteria that cause tuberculosis (TB) to better understand who might be at risk of developing the disease, with the hope of finding new ways to prevent and treat TB for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10874600 on NIH RePORTER |
What this research studies
This research investigates the immune responses involved in the progression of Mycobacterium tuberculosis (Mtb) infection to active tuberculosis (TB) disease. It focuses on the interactions between Mtb and alveolar macrophages, which are key immune cells in the lungs. By analyzing different strains of Mtb and their effects on the immune system, the study aims to identify biomarkers that can predict the risk of developing TB. Patients may benefit from insights that could lead to improved prevention and treatment strategies for TB.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been exposed to Mycobacterium tuberculosis or are at risk of developing tuberculosis.
Not a fit: Patients who are not at risk for tuberculosis or have already developed active TB disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better methods for predicting and preventing the progression of tuberculosis in at-risk individuals.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this specific approach to identifying biomarkers is relatively novel.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Salgame, Padmini — Rutgers Biomedical and Health Sciences
- Study coordinator: Salgame, Padmini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.