Understanding how tuberculosis bacteria transport nutrients
Structural characterization of MCE transport systems from Mycobacterium tuberculosis
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11012803
This study is looking at how the tuberculosis bacteria grab important nutrients from our cells to survive, and by understanding this process better, we hope to find new ways to fight the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11012803 on ClinicalTrials.gov |
What this research studies
This research investigates the transport systems used by Mycobacterium tuberculosis (Mtb) to import essential nutrients like cholesterol from host cells. By examining the structure and function of these transport systems, particularly the MCE (Mammalian Cell Entry) proteins, the research aims to uncover how Mtb survives and thrives within the human body. The approach involves advanced techniques such as cryo-electron microscopy to visualize these complex protein structures. This knowledge could lead to new strategies for combating tuberculosis by targeting these transport mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis, particularly those with drug-resistant forms of the disease.
Not a fit: Patients with non-infectious diseases or those not affected by tuberculosis will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel treatments for tuberculosis that effectively disrupt the bacteria's nutrient acquisition.
How similar studies have performed: Previous research on similar transport systems in other bacteria has shown promising results, indicating that this approach may yield valuable insights into tuberculosis treatment.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BHABHA, GIRA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: BHABHA, GIRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.