Understanding how tuberculosis bacteria transport nutrients
Official title: Structural characterization of MCE transport systems from Mycobacterium tuberculosis
Funded at Johns Hopkins University · NIH-11012803 · Data updated 2026-11-12
This study is looking at how the tuberculosis bacteria grab important nutrients from our cells to survive, and by understanding this process better, we hope to find new ways to fight the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 3, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $725,790 |
| NIH project number | 5R01AI174646-04 |
| Project ID | NIH-11012803 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with tuberculosis, particularly those with drug-resistant forms of the disease.
✕Less likely to help
Patients with non-infectious diseases or those not affected by tuberculosis will not benefit from this research.
What this research studies
This research investigates the transport systems used by Mycobacterium tuberculosis (Mtb) to import essential nutrients like cholesterol from host cells. By examining the structure and function of these transport systems, particularly the MCE (Mammalian Cell Entry) proteins, the research aims to uncover how Mtb survives and thrives within the human body. The approach involves advanced techniques such as cryo-electron microscopy to visualize these complex protein structures. This knowledge could lead to new strategies for combating tuberculosis by targeting these transport mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel treatments for tuberculosis that effectively disrupt the bacteria's nutrient acquisition.
How similar studies have gone: Previous research on similar transport systems in other bacteria has shown promising results, indicating that this approach may yield valuable insights into tuberculosis treatment.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Bhabha, Gira — Johns Hopkins University
- Study coordinator: Bhabha, Gira
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.