Understanding how tuberculosis bacteria survive in low-nutrient environments
Official title: Arginine Biosynthesis: A Metabolic Battery for Mycobacteria tuberculosis to Survive Aerosolization Stress
Funded at Weill Medical Coll of Cornell Univ · NIH-11020965 · Data updated 2026-11-12
This study looks at how the tuberculosis bacteria manage to survive when there aren't enough nutrients, especially when they are spread through the air, and it aims to find ways to help stop the spread of tuberculosis by understanding these survival tricks.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 5F30AI179167-02 |
| Project ID | NIH-11020965 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of tuberculosis infection or those who have been diagnosed with tuberculosis.
✕Less likely to help
Patients who are not at risk for tuberculosis or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates how Mycobacterium tuberculosis, the bacteria that causes tuberculosis, adapts to survive in environments with limited nutrients, particularly when aerosolized. The study focuses on the metabolic pathways, specifically arginine biosynthesis, that allow the bacteria to thrive despite the challenges of nutrient deprivation. By examining these mechanisms, the research aims to identify potential targets for interventions that could reduce the transmission of tuberculosis. The approach includes laboratory experiments to analyze the bacteria's response to changes in its environment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing the transmission of tuberculosis, ultimately reducing its incidence and improving public health.
How similar studies have gone: Previous research has shown promise in targeting metabolic pathways in bacteria, suggesting that this approach could yield significant insights into tuberculosis transmission.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Nazia, Sakila Zaman — Weill Medical Coll of Cornell Univ
- Study coordinator: Nazia, Sakila Zaman
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.