Understanding how tuberculosis bacteria manage their genetic information
Official title: Structural and functional studies of the mycobacterial transcription cycle
Funded at Rockefeller University · NIH-11004085 · Data updated 2026-11-12
This study is looking at how the TB bacteria work and survive, especially when it comes to resisting antibiotics, so that we can find new ways to create effective treatments for people with drug-resistant TB.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $381,375 |
| NIH project number | 5R35GM151879-02 |
| Project ID | NIH-11004085 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with tuberculosis, especially those with antibiotic-resistant strains.
✕Less likely to help
Patients with non-bacterial infections or those who do not have tuberculosis will likely not benefit from this research.
What this research studies
This research investigates the transcription cycle of Mycobacterium tuberculosis, the bacteria responsible for tuberculosis (TB). By examining the RNA polymerase enzyme and its interactions with various transcription factors, the study aims to uncover the mechanisms that allow TB bacteria to survive and resist antibiotics. The research employs advanced techniques like cryo-electron microscopy to visualize these processes at a molecular level. This knowledge could lead to the development of new antibiotics that are effective against drug-resistant strains of TB.
Why it matters
Potential benefit: If successful, this research could lead to the creation of new antibiotics that effectively combat tuberculosis, particularly drug-resistant forms.
How similar studies have gone: Previous research has shown success in targeting RNA polymerase for antibiotic development, indicating a promising avenue for this study.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Campbell, Elizabeth a — Rockefeller University
- Study coordinator: Campbell, Elizabeth a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.