Understanding how tuberculosis bacteria divide to develop new treatments
Official title: Membrane Protein Complexes in the M. Tuberculosis Divisome: Structures and Interactions
Funded at Florida State University · NIH-11130365 · Data updated 2026-11-12
This study is looking at how the bacteria that cause tuberculosis divide, with the goal of finding new treatments for drug-resistant tuberculosis, so patients can have better options for getting well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $721,194 |
| NIH project number | 1R01AI185198-01A1 |
| Project ID | NIH-11130365 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with tuberculosis, especially those with multi-drug resistant strains.
✕Less likely to help
Patients with non-tuberculosis related conditions or those who do not have active tuberculosis may not benefit from this research.
What this research studies
This research focuses on the mechanisms of cell division in the tuberculosis-causing bacteria, Mycobacterium tuberculosis. By examining the structures and interactions of specific protein complexes involved in this process, the research aims to uncover new ways to combat drug-resistant tuberculosis. The approach involves detailed structural characterizations to identify how these proteins function differently from those in other bacteria, which could lead to the development of innovative therapies. Patients may benefit from new treatments that effectively target drug-resistant strains of tuberculosis.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies for tuberculosis, particularly for drug-resistant cases.
How similar studies have gone: While research on tuberculosis has been ongoing, the specific approach of targeting the divisome's protein complexes for new drug development is relatively novel.
Where this research is happening
-
Florida State University
Tallahassee, United States Active
Researchers
- Principal investigator: Hu, Yan-Yan — Florida State University
- Study coordinator: Hu, Yan-Yan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.