Understanding how tuberculosis bacteria control gene expression and repair DNA
Molecular Mechanisms of Transcription Initiation and DNA Repair
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-11036404
This study is looking at how the tuberculosis bacteria work and fix their DNA, with the goal of finding new ways to create antibiotics, especially for those tough strains that don't respond to current treatments, so we can help people who are affected by this serious disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11036404 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular pathways of Mycobacterium tuberculosis, the bacteria responsible for tuberculosis, focusing on how it regulates gene expression and repairs its DNA. By studying transcription regulation and DNA repair mechanisms, the research aims to uncover new targets for antibiotic development, especially in light of rising drug-resistant strains. The approach includes both ensemble and single-molecule experiments, along with kinetic modeling, to understand how transcription factors interact with DNA. This work is crucial for developing new treatments for a disease that causes millions of infections and deaths each year.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with Mycobacterium tuberculosis, particularly those with drug-resistant strains.
Not a fit: Patients who do not have tuberculosis or are not infected with Mycobacterium tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that are effective against drug-resistant tuberculosis.
How similar studies have performed: Previous research has shown success in targeting molecular mechanisms of bacterial pathogens, indicating potential for breakthroughs in tuberculosis treatment.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GALBURT, ERIC A — WASHINGTON UNIVERSITY
- Study coordinator: GALBURT, ERIC A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.