Understanding how tuberculosis and HIV interact and affect treatment outcomes
Official title: Investigating Multiple PK and PD Relationships for TB-HIV (IMPPRove TB-HIV)
Funded at Vanderbilt University Medical Center · NIH-10882249 · Data updated 2026-11-12
This study is looking at how tuberculosis (TB) and HIV affect each other’s treatment, aiming to find the best ways to help people who have both infections get better by checking how well their medications are working.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 21, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $817,252 |
| NIH project number | 1R56AI174911-01A1 |
| Project ID | NIH-10882249 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary tuberculosis, particularly those who are also living with HIV.
✕Less likely to help
Patients who do not have tuberculosis or HIV, or those with other unrelated health conditions, may not benefit from this research.
What this research studies
This research investigates the complex relationship between tuberculosis (TB) and HIV, focusing on how these two diseases impact each other's treatment outcomes. By analyzing drug concentrations and patient responses, the study aims to identify optimal drug exposure levels necessary for effective TB treatment, especially in patients co-infected with HIV. Using a large global cohort, researchers will collect samples to measure drug levels and adherence, helping to understand the risks of treatment failure or recurrence. The findings could lead to improved treatment strategies for individuals suffering from both conditions.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment protocols for patients with TB and HIV, ultimately improving survival rates and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding drug interactions and treatment outcomes in TB and HIV co-infection, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Dooley, Kelly E. — Vanderbilt University Medical Center
- Study coordinator: Dooley, Kelly E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.