Understanding how tuberculosis affects people living with HIV
Mentoring in Immunometabolic Dysregulation in TB and TB/HIV
This study is looking at how the immune system works in people with HIV who might have tuberculosis (TB), to find out what makes some people stay healthy while others get sick, so we can create better tests and treatments for those at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10873668 on NIH RePORTER |
What this research studies
This research investigates the immune mechanisms that control tuberculosis (TB) in individuals living with HIV. It aims to identify unique metabolic and microRNA profiles that can help distinguish between those with latent TB infection and those who may progress to active TB disease. By utilizing biorepositories from India and South Africa, the study will analyze samples from household contacts of TB patients to better understand the risk factors associated with TB progression. The goal is to improve diagnostic tests and preventive therapies for this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who may have latent TB infection.
Not a fit: Patients who do not have HIV or those without latent TB infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and preventive strategies for tuberculosis in people living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in TB, but this specific approach of using metabolic and microRNA profiling is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Karakousis, Petros C — Johns Hopkins University
- Study coordinator: Karakousis, Petros C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.