Understanding how trypsin activates in pancreatitis
Official title: Mechanisms of Trypsin Activation in Pancreatitis
Funded at Boston University Medical Campus · NIH-11009499 · Data updated 2026-11-12
This study is looking at how a digestive enzyme called trypsin gets activated in the pancreas, which is an important step in the development of pancreatitis, to help find better ways to understand and treat people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 9, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $326,700 |
| NIH project number | 5R01DK132471-03 |
| Project ID | NIH-11009499 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of pancreatitis or those with genetic predispositions to the condition.
✕Less likely to help
Patients who do not have pancreatitis or related digestive disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the digestive enzyme trypsin is activated in the pancreas, which is a critical early event in the development of pancreatitis. The study aims to clarify the roles of different activation pathways, including the potential influence of genetic mutations and the enzyme cathepsin B. By conducting experiments on animal models, the researchers will explore how these factors contribute to the severity and onset of pancreatitis. This knowledge could lead to better understanding and treatment options for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for pancreatitis, potentially reducing its severity and onset in affected patients.
How similar studies have gone: Previous research has shown promise in understanding enzyme activation in similar contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Geisz-Fremy, Andrea — Boston University Medical Campus
- Study coordinator: Geisz-Fremy, Andrea
Related research
Other NIH-funded projects on the same topics.
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Chronic Pancreatitis and Related Conditions Data Center Supports Multi-Center Research
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Lymphatic roles in pancreatitis and recovery
This project looks at how the lymphatic system influences inflammation and healing in pancreatitis, using mouse models to identify new therapeutic targets.
-
Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
-
Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
-
Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
-
Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.