Understanding how Trypanosoma cruzi uses a feeding structure to infect humans
Elucidating the Role of Endocytosis Via the Cytostome in the Life Cycle of Trypanosoma cruzi
This study is looking at how the Chagas disease parasite, Trypanosoma cruzi, feeds and survives by examining a special part of its structure, and it aims to find new ways to fight the disease that affects people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-11089420 on NIH RePORTER |
What this research studies
This research investigates the life cycle of Trypanosoma cruzi, the parasite responsible for Chagas disease, focusing on a unique feeding structure called the cytostome. By utilizing advanced CRISPR/Cas9 gene editing technology, the study aims to explore how this parasite endocytoses materials from its environment, which is crucial for its survival and infection process. The research will involve detailed molecular analyses to better understand the dynamics of this feeding organelle during the parasite's life cycle. Insights gained from this research could lead to improved strategies for combating Chagas disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals living in endemic regions of Chagas disease, particularly those who may be at risk of infection.
Not a fit: Patients who are not affected by Chagas disease or do not live in endemic areas are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or preventive measures for Chagas disease, potentially benefiting millions of affected individuals.
How similar studies have performed: While research on Trypanosoma cruzi has been limited, the use of CRISPR/Cas9 technology in studying similar parasites has shown promising results in other contexts.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Etheridge, Ronald Drew — University of Georgia
- Study coordinator: Etheridge, Ronald Drew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.