Understanding how Trypanosoma brucei cells maintain their shape and divide
Biogenesis of the Trypanosoma brucei subpellicular microtubule array
This study looks at the tiny structures inside the Trypanosoma brucei parasite, which causes African sleeping sickness, to understand how they help the parasite keep its shape and divide, with the hope that this knowledge could lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10901985 on NIH RePORTER |
What this research studies
This research investigates the cellular structure of Trypanosoma brucei, the parasite responsible for African sleeping sickness. It focuses on the subpellicular microtubule array, which is crucial for the parasite's shape and successful cell division. By studying specific proteins that help organize and duplicate this microtubule structure, the research aims to uncover fundamental mechanisms that could lead to new treatment strategies. Patients may benefit from insights gained into how these parasites function and how to disrupt their life cycle.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by African sleeping sickness or those at risk of infection.
Not a fit: Patients with other unrelated conditions or those not affected by trypanosomatid infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies for African sleeping sickness and other diseases caused by trypanosomatids.
How similar studies have performed: Other research has shown success in targeting cellular structures of parasites, indicating potential for breakthroughs in this area.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: De Graffenried, Christopher Luis — Brown University
- Study coordinator: De Graffenried, Christopher Luis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.