Understanding how TRPV channels work in the body
Structure and Function of TRPV channels
This study is looking at special channels in our cells that help with important body functions, like how our nerves develop and how our kidneys manage calcium, to find out how they work and how they can be better targeted for treating related health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11007267 on NIH RePORTER |
What this research studies
This research focuses on the TRPV channels, specifically TRPV2 and TRPV5, which are important for various physiological functions. The study aims to uncover the molecular mechanisms that control how these channels operate and their roles in processes like neuronal development, immunity, and calcium balance in the kidneys. By using advanced techniques such as cryo-electron microscopy, researchers will explore how these channels are activated and regulated by different substances. This knowledge could lead to new insights into treating conditions related to these channels.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting calcium homeostasis, such as kidney disorders or certain types of cancer.
Not a fit: Patients with unrelated health issues or those not experiencing calcium regulation problems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases related to calcium regulation, such as certain cancers and cardiovascular conditions.
How similar studies have performed: Previous research has shown promising results in understanding TRP channels, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Moiseenkova-Bell, Vera — University of Pennsylvania
- Study coordinator: Moiseenkova-Bell, Vera
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.