Understanding how tRNA affects pancreatic cancer outcomes
Official title: Investigating tRNA biology as a prognostic and oncogenic feature in pancreatic adenocarcinoma
Funded at Johns Hopkins University · NIH-11001096 · Data updated 2026-11-12
This study is looking at how certain types of tRNA might affect the growth and treatment response of pancreatic cancer, with the goal of finding new ways to help patients get better care tailored to their specific cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30CA284534-02 |
| Project ID | NIH-11001096 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma.
✕Less likely to help
Patients with other types of cancer or those without a diagnosis of pancreatic cancer may not benefit from this research.
What this research studies
This research investigates the role of transfer RNA (tRNA) in pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer that is challenging to treat. The study aims to explore how variations in tRNA can influence the behavior of cancer cells, particularly their growth and response to treatments. By examining the relationship between tRNA levels and the molecular characteristics of PDAC, researchers hope to identify new prognostic markers and therapeutic targets. Patients may benefit from insights that could lead to more effective treatment strategies based on their specific cancer subtype.
Why it matters
Potential benefit: If successful, this research could lead to improved prognostic tools and targeted therapies for patients with pancreatic cancer.
How similar studies have gone: Previous research has shown promising results in understanding the role of tRNA in cancer biology, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Kawalerski, Ryan — Johns Hopkins University
- Study coordinator: Kawalerski, Ryan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.