Understanding how tRNA affects brain function and seizure susceptibility
The Function of the Cytoplasmic tRNA Repertoire in the Cellular and Molecular Homeostasis of the Mammalian Brain
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11002706
This study is looking at how certain tiny molecules in our brain, called tRNAs, help keep our brain cells working properly, especially in people with absence epilepsy, to see if changes in these molecules can affect seizures and brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11002706 on ClinicalTrials.gov |
What this research studies
This research investigates the role of transfer RNAs (tRNAs) in maintaining the balance of cellular functions in the mammalian brain, particularly in relation to absence epilepsy. The study focuses on how specific tRNA genes, especially those linked to the amino acid arginine, influence gene expression and neuronal activity. By examining the effects of mutations in these tRNA genes, the research aims to uncover mechanisms that could lead to altered seizure susceptibility and brain function. Patients may benefit from insights gained into how tRNA processing impacts neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with absence epilepsy or related seizure disorders.
Not a fit: Patients with seizure disorders not related to tRNA function or those without neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing absence epilepsy and improving brain health.
How similar studies have performed: While the specific focus on tRNA in the context of absence epilepsy is novel, related research has shown that understanding genetic factors in seizure disorders can lead to significant advancements in treatment.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ACKERMAN, SUSAN L — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: ACKERMAN, SUSAN L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Absence Seizure Disorder