Understanding how trisomy 21 affects brain development and function
Human cortical development and neural plasticity altered by trisomy 21
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11145382
This study is looking at how Down syndrome affects brain development and thinking skills by using special cells to create a map of the brain, which could help us understand the challenges people with Down syndrome face in learning and memory.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11145382 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind cognitive impairment in individuals with Down syndrome (trisomy 21) by using human induced pluripotent stem cells to model brain development. The team will create a detailed atlas of the prenatal cortex in Down syndrome to identify how specific neurons and synaptic connections are altered during development. By integrating molecular data from both living and lab-grown cells, the research aims to uncover the pathways disrupted by trisomy 21 that lead to intellectual disabilities. This approach could provide valuable insights into the biological basis of cognitive challenges faced by individuals with Down syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome, particularly those under 21 years old.
Not a fit: Patients without Down syndrome or those over 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for cognitive impairments associated with Down syndrome.
How similar studies have performed: Previous research has shown promise in using stem cell models to study genetic disorders, indicating potential for success in this novel approach.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BHATTACHARYYA, ANITA — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: BHATTACHARYYA, ANITA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.