Understanding how Trisomy 21 affects brain cell development and function
Investigating Trisomy 21 Impact on Human Neural Cell Development and Function Using "Trisomy Silencing" in vitro
['FUNDING_FELLOWSHIP'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-10898821
This study is looking at how Down syndrome affects brain cells and could help us understand the link between Down syndrome and early Alzheimer's disease, which might lead to better treatments for those facing these challenges.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-10898821 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of Trisomy 21, which causes Down syndrome, on the development and function of human neural cells. By using advanced techniques such as manipulating gene expression in cell lines, the study aims to clarify how the overexpression of genes on chromosome 21 affects brain development and contributes to early-onset Alzheimer's disease. The research will analyze various brain cell types and identify when and how these effects occur, providing insights into potential therapeutic targets. Patients may benefit from a better understanding of the neurological challenges associated with Down syndrome and Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Down syndrome or those at risk for early-onset Alzheimer's disease.
Not a fit: Patients without Down syndrome or those not affected by Alzheimer's disease may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing or preventing neurological disorders in individuals with Down syndrome.
How similar studies have performed: Previous research has shown varying results regarding the impact of Trisomy 21 on brain development, indicating that this area is still being explored and holds potential for new discoveries.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LARSEN, ERIC CHRISTOPHER — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: LARSEN, ERIC CHRISTOPHER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease