Understanding how triple-negative breast cancer affects immune cell behavior
Official title: Unveiling how the molecular landscape of TNBC sculps intratumoral macrophage origin and function
Funded at Baylor College of Medicine · NIH-10901734 · Data updated 2026-11-12
This study is looking at how different types of triple-negative breast cancer affect immune cells called macrophages in tumors, with the goal of finding better treatments that work specifically for each type of cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $51,974 |
| NIH project number | 1F31CA281063-01A1 |
| Project ID | NIH-10901734 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with triple-negative breast cancer.
✕Less likely to help
Patients with other subtypes of breast cancer or those without a diagnosis of breast cancer may not benefit from this research.
What this research studies
This research investigates the relationship between the molecular characteristics of triple-negative breast cancer (TNBC) and the origins and functions of immune cells called macrophages within tumors. By examining different TNBC subtypes, the study aims to identify how these tumors influence macrophage behavior, which could lead to more effective therapies targeting the tumor microenvironment. The approach involves analyzing the origins of macrophages and their functional profiles to better understand their roles in TNBC progression. This could pave the way for developing new treatments that are tailored to the specific molecular signatures of TNBC.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with triple-negative breast cancer by targeting the tumor's immune environment.
How similar studies have gone: Previous research has shown promise in targeting the tumor microenvironment in various cancers, suggesting that this approach may yield beneficial results for TNBC as well.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Rivas, Charlotte Helena — Baylor College of Medicine
- Study coordinator: Rivas, Charlotte Helena
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.