Understanding how TRIM14 affects immune responses to tuberculosis
Official title: TRIM 14 is a master regulator of STAT3 activity during the macrophage innate immune responses to Mycobacterium tuberculosis
Funded at Texas A&m University Health Science Ctr · NIH-11003284 · Data updated 2026-11-12
This study is looking at how a protein called TRIM14 helps our immune system fight off tuberculosis, the bacteria that causes TB, by working with another protein, STAT3, to keep our cells healthy; the goal is to find ways to boost our body's defenses against this infection.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $37,797 |
| NIH project number | 5F31AI176795-02 |
| Project ID | NIH-11003284 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are infected with Mycobacterium tuberculosis or are at high risk for tuberculosis.
✕Less likely to help
Patients who do not have tuberculosis or are not at risk for this infection may not benefit from this research.
What this research studies
This research investigates the role of a protein called TRIM14 in regulating immune responses to Mycobacterium tuberculosis, the bacteria that causes tuberculosis. It focuses on how TRIM14 influences another protein, STAT3, which is important for maintaining mitochondrial health and immune function. By studying how these proteins interact during infection, the research aims to uncover new insights into the body's defense mechanisms against this serious bacterial infection. Patients may benefit from a better understanding of how to enhance immune responses to tuberculosis.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving immune responses in patients with tuberculosis.
How similar studies have gone: Other research has shown promising results in understanding immune responses to bacterial infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Mabry, Cory — Texas A&m University Health Science Ctr
- Study coordinator: Mabry, Cory
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.