Understanding how Trichomonas vaginalis affects vaginal bacteria and immune response
RP-Riestra/Sussman: Investigating the Antibacterial and Immune Modulating Effects of Trichomonas Vaginalis Infection and Pyroptosis
This study is looking at how the parasite that causes trichomoniasis affects the good bacteria in the vagina that help keep it healthy, and it’s especially important for women, particularly those from racial and ethnic minority groups who are more affected by this infection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-11172387 on NIH RePORTER |
What this research studies
This research investigates the impact of the sexually transmitted parasite Trichomonas vaginalis on beneficial vaginal bacteria, specifically Lactobacillus species. It aims to uncover the molecular mechanisms by which T. vaginalis kills these protective bacteria and how this process may trigger an inflammatory response known as pyroptosis. By using advanced techniques like live/dead staining and pharmacological inhibitors, the study will explore the interactions between the parasite and the bacteria, as well as the potential antibacterial effects of pyroptosis. This research is particularly focused on the implications for women's health, especially among racial and ethnic minorities who are disproportionately affected by trichomoniasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are diagnosed with trichomoniasis or are experiencing symptoms related to bacterial vaginosis.
Not a fit: Patients who do not have a history of trichomoniasis or related vaginal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating bacterial vaginosis and other related infections in women.
How similar studies have performed: While the specific interactions between T. vaginalis and vaginal bacteria are understudied, related research on inflammatory responses and bacterial interactions has shown promising results.
Where this research is happening
San Diego, United States
- San Diego State University — San Diego, United States (Active)
Researchers
- Principal investigator: Riestra, Angelica M — San Diego State University
- Study coordinator: Riestra, Angelica M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.