Understanding how traumatic brain injury affects Alzheimer's disease and related dementias
Official title: Neuroimaging and clinical Endpoints With High-dimensional analysis Of Pathological Endophenotypes in TBI (NEW-HOPE-TBI)
Funded at University of Washington · NIH-10894533 · Data updated 2026-11-12
This study is looking at how injuries to the brain might be linked to Alzheimer's and similar memory problems, and it's for people who have had a traumatic brain injury to help researchers learn more and find better ways to diagnose and treat these conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,756,811 |
| NIH project number | 1U01NS137484-01 |
| Project ID | NIH-10894533 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals aged 21 and older who have experienced traumatic brain injuries or are at risk for Alzheimer's disease and related dementias.
✕Less likely to help
Patients who do not have a history of traumatic brain injury or are not at risk for Alzheimer's disease or related dementias may not benefit from this research.
What this research studies
This research investigates the connections between traumatic brain injury (TBI) and the development of Alzheimer's disease and related dementias (ADRD). By analyzing neuroimaging and pathological data, the study aims to uncover how different patterns of head trauma can lead to or accelerate these conditions. Patients will contribute to a nationwide network that collects and shares biospecimens and imaging data, enhancing the understanding of these diseases. The goal is to improve diagnostic strategies and develop effective treatments for those affected.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and therapeutic interventions for patients with Alzheimer's disease and related dementias.
How similar studies have gone: Other research has shown promising results in understanding the links between traumatic brain injury and neurodegenerative diseases, indicating that this approach has potential for significant advancements.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Keene, Christopher Dirk — University of Washington
- Study coordinator: Keene, Christopher Dirk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.