Understanding how trauma and alcohol affect blood vessel leakage
Microvascular Leakage in Hemorrhagic Shock and Trauma
This study is looking at how injuries and alcohol use can cause tiny blood vessels to leak, and it aims to find new ways to help patients recover better from trauma and avoid serious complications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10861787 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind microvascular leakage that occurs during traumatic injuries, particularly in patients who are also experiencing alcohol intoxication. By exploring the cellular and molecular signals that control blood vessel permeability, the study aims to identify new therapeutic targets that could improve patient outcomes. Advanced techniques such as RNA sequencing and proteomics will be used to analyze changes in gene expression and molecular profiles related to this condition. The ultimate goal is to enhance treatment strategies for trauma patients who often face severe complications like sepsis and organ failure.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced traumatic injuries, especially those with concurrent alcohol intoxication.
Not a fit: Patients who have not experienced trauma or alcohol intoxication may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce complications and enhance recovery for trauma patients.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown promise in understanding microvascular responses in trauma settings.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Breslin, Jerome W — University of South Florida
- Study coordinator: Breslin, Jerome W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.