Understanding how trauma affects blood vessel function and clotting
Trauma and Shock-Induced Microvascular Dysregulation and Coagulopathy
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11014064
This study looks at how trauma and shock can affect tiny blood vessels and lead to problems with blood clotting, aiming to find ways to help patients who have been injured feel better and recover more effectively.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11014064 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of trauma and shock on the microvascular system, particularly how these conditions lead to blood clotting disorders. It focuses on the loss of a protective layer on blood vessels, which can result in increased bleeding and complications after injury. By studying the mechanisms behind these changes, the research aims to identify potential therapeutic targets to improve patient outcomes. Patients who have experienced trauma may be monitored for changes in their blood vessel function and clotting ability as part of this investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced significant trauma or hemorrhagic shock.
Not a fit: Patients with chronic bleeding disorders unrelated to trauma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from trauma-related bleeding and clotting disorders.
How similar studies have performed: Previous research has shown promising results in understanding microvascular dysregulation and its impact on coagulation in trauma patients, suggesting that this approach has potential for significant advancements.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOZAR, ROSEMARY A — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: KOZAR, ROSEMARY A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bleeding disorder