Understanding how transposable elements affect genome stability and fertility
Official title: Co-evolutionary dynamics between transposable elements and their hosts
Funded at North Dakota State University · NIH-10939709 · Data updated 2026-11-12
This study looks at how certain genetic elements can affect the health and fertility of living things, using fruit flies to understand how tiny RNA molecules help protect against these effects, which could lead to better treatments for people facing fertility issues or genetic problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Dakota State University NIH-funded |
| Lab location | 1 site (Fargo, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $362,500 |
| NIH project number | 1R35GM155272-01 |
| Project ID | NIH-10939709 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals experiencing fertility challenges potentially linked to genetic factors.
✕Less likely to help
Patients with fertility issues unrelated to genomic stability or transposable elements may not receive direct benefits from this research.
What this research studies
This research investigates the relationship between transposable elements and their host organisms, focusing on how these elements can disrupt genome stability, which is crucial for fertility and overall health. The study utilizes a model organism, Drosophila melanogaster, to explore the mechanisms by which small RNA molecules, specifically piRNA, help defend against the harmful effects of these elements. By examining both somatic and germline cells, the research aims to uncover the complex systems that organisms use to maintain genomic integrity. Patients may benefit from insights gained about fertility and genetic stability that could inform future treatments or preventative measures.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for fertility issues related to genomic instability.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown success in understanding the role of piRNA in genome stability and fertility in model organisms.
Where this research is happening
-
North Dakota State University
Fargo, United States Active
Researchers
- Principal investigator: Signor, Sarah — North Dakota State University
- Study coordinator: Signor, Sarah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.