Understanding how transplanted cells respond in the body for diabetes treatment
Official title: Monitoring graft responses to the transplant niche in allogeneic cell replacement therapy
Funded at Minutia, INC. · NIH-10931682 · Data updated 2026-11-12
This study is looking at how transplanted cells for people with Type 1 Diabetes work with the immune system and the body, so we can find better ways to keep those cells healthy and safe from stress, helping them work better for you.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Minutia, INC. NIH-funded |
| Lab location | 1 site (Oakland, United States) |
| Project start | September 6, 2021 |
| Project end | August 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $870,000 |
| NIH project number | 5R44DK130034-03 |
| Project ID | NIH-10931682 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Type 1 Diabetes who are considering or have undergone cell transplantation.
✕Less likely to help
Patients with Type 2 Diabetes or those who are not candidates for cell transplantation may not benefit from this research.
What this research studies
This research investigates how transplanted cells for Type 1 Diabetes patients interact with the immune system and the surrounding environment in the body. It aims to develop methods to monitor the health of these transplanted cells and identify when they are under stress from inflammation. By understanding these responses, the researchers hope to create targeted therapies that can protect the transplanted cells and improve their chances of success. The approach includes using advanced biosensing techniques to track the graft's condition in real-time.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for patients receiving cell transplants for Type 1 Diabetes, potentially reducing the need for multiple transplants.
How similar studies have gone: Previous research has shown promise in using biosensing techniques to monitor graft health, indicating that this approach could be effective.
Where this research is happening
-
Minutia, INC.
Oakland, United States Active
Researchers
- Principal investigator: Digovich, Catherine — Minutia, INC.
- Study coordinator: Digovich, Catherine
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.