Understanding how transcription is regulated in cells
Regulation of Archaeal Transcription
This study is looking at how our genes are turned on and off in cells, which could help us understand diseases like cancer better and lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-11059939 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control gene expression in both archaeal and eukaryotic cells, focusing on the regulation of transcription after it has started. The team aims to uncover how changes in chromatin structure can influence gene expression and how transcription can be accurately terminated. By exploring these fundamental processes, the research seeks to fill significant knowledge gaps that could have implications for understanding diseases, including cancer. Patients may benefit from insights gained about gene regulation that could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene expression dysregulation, such as certain cancers.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by transcriptional regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases associated with abnormal gene expression, including various cancers.
How similar studies have performed: Other research has shown success in understanding transcription regulation, but this specific approach focusing on archaeal systems is relatively novel.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Santangelo, Thomas James — Colorado State University
- Study coordinator: Santangelo, Thomas James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.