Understanding how transcription hubs in cells are formed and function
Probing the Formation and Function of Transcription Hubs
This study is looking at special areas in our genes that help control how cells grow and stay healthy, focusing on a protein called YAP, and it hopes to find new ways to understand and treat diseases like cancer and neurodegeneration that can happen when these areas don’t work properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11094115 on NIH RePORTER |
What this research studies
This research investigates transcription hubs, which are critical areas in the genome where gene transcription occurs. By using advanced imaging and proteomics techniques, the study aims to uncover how these hubs are formed and how they function in regulating genes essential for cell identity and survival. The research focuses on a specific protein, Yes-associated Protein (YAP), to explore its role in the formation of these hubs and their impact on cell proliferation. Patients may benefit from insights gained about the dysregulation of transcription hubs, which is linked to diseases like cancer and neurodegeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to dysregulated gene transcription, including various cancers and neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to transcription regulation or those not experiencing any genetic transcription issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with transcription hub dysregulation, such as cancer.
How similar studies have performed: Other research has shown promising results in understanding gene regulation through similar approaches, indicating potential for success in this area.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Cai, Danfeng — Johns Hopkins University
- Study coordinator: Cai, Danfeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.