Understanding how transcription factors influence cell development and disease
Official title: Mechanisms driving complex reproducible outcomes
Funded at University of Pennsylvania · NIH-11089944 · Data updated 2026-11-12
This study is looking at how certain proteins help control how cells develop and grow, which could help us understand why some people get diseases like cancer or autoimmune disorders, so that we can find better ways to help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $406,250 |
| NIH project number | 1R35GM158110-01 |
| Project ID | NIH-11089944 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancers, neurodevelopmental disorders, cardiovascular diseases, or autoimmune conditions.
✕Less likely to help
Patients with conditions unrelated to developmental pathways or transcription factor dysregulation may not benefit from this research.
What this research studies
This research investigates the mechanisms by which transcription factors (TFs) control the complex processes of cell development from single-cell precursors. It aims to uncover how these factors coordinate developmental pathways and maintain reproducibility in the face of genetic and environmental challenges. By studying the functional divergence of TFs, the research seeks to identify unique gene regulation patterns that could explain the emergence of various diseases, including cancers and autoimmune disorders. Patients may benefit from insights gained about how these processes can go awry and lead to health issues.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases linked to developmental dysregulation.
How similar studies have gone: Previous research has shown promising results in understanding transcription factor roles in development and disease, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Husbands, Aman Yebio — University of Pennsylvania
- Study coordinator: Husbands, Aman Yebio
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.