Understanding how trained immunity affects kidney transplant patients
Official title: Elucidating the role of trained immunity in kidney transplant patients
Funded at Icahn School of Medicine at Mount Sinai · NIH-11064093 · Data updated 2026-11-12
This study is looking at how the immune system's memory affects kidney transplant patients, hoping to find ways to help their bodies accept the new kidney better and improve their overall health after the transplant.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $323,380 |
| NIH project number | 5P01AI168258-03 |
| Project ID | NIH-11064093 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have undergone kidney transplantation and are experiencing challenges related to graft rejection.
✕Less likely to help
Patients who have not received a kidney transplant or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the role of trained immunity, a form of innate immune memory, in kidney transplant patients. It aims to understand how this immune response can influence graft rejection and long-term transplant success. By analyzing circulating factors and immune cell behavior, the study seeks to identify ways to modulate these responses to improve patient outcomes. The approach includes both preclinical models and clinical data from kidney transplant patients to validate findings.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing kidney transplant rejection and enhancing long-term graft survival.
How similar studies have gone: Preliminary data from similar studies in heart transplantation have shown promising results, indicating that targeting trained immunity may be a viable approach.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Mulder, Willem — Icahn School of Medicine at Mount Sinai
- Study coordinator: Mulder, Willem
Related research
Other NIH-funded projects on the same topics.
-
Microbial clues to diagnose and predict infections in kidney transplant patients
A patient-focused project will look for microbial biomarkers in stool, blood, and urine to help doctors predict and diagnose infections in people who have had a kidney transplant.
-
Immunological mechanisms behind treatment-resistant kidney transplant rejection
This grant explores why certain kidney transplant rejections don’t respond to standard treatments and what immune cells in the graft are driving that resistance.
-
Complement-Bound Exosomes and Kidney Transplant Immunity
This project studies how kidney transplant injury and rejection happen after surgery and whether blocking certain immune pathways during organ preservation could improve transplant outcomes.
-
Blood vessel signals predicting heart problems after kidney transplant
This project studies blood markers and tissue patterns after kidney transplants to identify which patients are at highest risk of cardiovascular problems.
-
Understanding how BK virus links infection to kidney transplant rejection
This project looks at how BK polyomavirus reactivation affects kidney transplant patients and aims to use pre-transplant T cell information to tailor immunosuppression and monitoring.
-
Characterization of a LILRB3 SNP cluster and its link to kidney transplant outcomes
A study in kidney transplant recipients looks at genetic factors that may be tied to higher risk of graft failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.