Understanding how trained immunity affects kidney transplant patients
Elucidating the role of trained immunity in kidney transplant patients
This study is looking at how the immune system's memory affects kidney transplant patients, hoping to find ways to help their bodies accept the new kidney better and improve their overall health after the transplant.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11064093 on NIH RePORTER |
What this research studies
This research investigates the role of trained immunity, a form of innate immune memory, in kidney transplant patients. It aims to understand how this immune response can influence graft rejection and long-term transplant success. By analyzing circulating factors and immune cell behavior, the study seeks to identify ways to modulate these responses to improve patient outcomes. The approach includes both preclinical models and clinical data from kidney transplant patients to validate findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone kidney transplantation and are experiencing challenges related to graft rejection.
Not a fit: Patients who have not received a kidney transplant or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing kidney transplant rejection and enhancing long-term graft survival.
How similar studies have performed: Preliminary data from similar studies in heart transplantation have shown promising results, indicating that targeting trained immunity may be a viable approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Mulder, Willem — Icahn School of Medicine at Mount Sinai
- Study coordinator: Mulder, Willem
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.